Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy.

ABSTRACT:

Objective

To examine sex differences in the relationship between clinical symptoms related to Alzheimer disease (AD) (verbal memory deficits) and neurodegeneration (hippocampal volume/intracranial volume ratio [HpVR]) across AD stages.

Methods

The sample included 379 healthy participants, 694 participants with amnestic mild cognitive impairment (aMCI), and 235 participants with AD and dementia from the Alzheimer's Disease Neuroimaging Initiative who completed the Rey Auditory Verbal Learning Test (RAVLT). Cross-sectional analyses were conducted using linear regression to examine the interaction between sex and HpVR on RAVLT across and within diagnostic groups adjusting for age, education, and APOE ε4 status.

Results

Across groups, there were significant sex × HpVR int

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC4831033 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature