Age at onset and Parkinson disease phenotype.

ABSTRACT:

Objective

To explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated PD.

Methods

We have analyzed baseline data from the Parkinson's Progression Markers Initiative database. Four hundred twenty-two patients with a diagnosis of PD confirmed by DaTSCAN imaging were divided into 4 groups according to age at onset (onset younger than 50 years, 50-59 years, 60-69 years, and 70 years or older) and investigated for differences in side, type and localization of symptoms, occurrence/severity of motor and nonmotor features, nigrostriatal function, and CSF biomarkers.

Results

Older age at onset was associated with a more severe motor and nonmotor phenotype, a greater dopaminergic dysfunctio

SUBMITTER: Pagano G 

PROVIDER: S-EPMC4831034 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature