Neuroinflammation in treated HIV-positive individuals: A TSPO PET study.

ABSTRACT:

Objective

To explore the effects of microglial activation on brain function and structure, and its relationship with peripheral inflammatory markers, in treated, HIV-positive individuals, using in vivo [(11)C]PBR28 PET (to measure the 18 kDa translocator protein [TSPO]).

Methods

Cognitively healthy HIV-positive individuals on suppressive antiretroviral therapy and HIV-negative individuals (controls) underwent brain [(11)C]PBR28 PET and MRI. HIV-positive patients completed neuropsychological testing and CSF testing for chemokines. The concentration of bacterial ribosomal 16sDNA in plasma was measured as a marker of microbial translocation.

Results

HIV-positive individuals showed global increases in TSPO expression compared to controls (corrected p < 0.01), with signifi

SUBMITTER: Vera JH 

PROVIDER: S-EPMC4831035 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature