Frontotemporal networks and behavioral symptoms in primary progressive aphasia.

ABSTRACT:

Objective

To determine if behavioral symptoms in patients with primary progressive aphasia (PPA) were associated with degeneration of a ventral frontotemporal network.

Methods

We used diffusion tensor imaging tractography to quantify abnormalities of the uncinate fasciculus that connects the anterior temporal lobe and the ventrolateral frontal cortex. Two additional ventral tracts were studied: the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus. We also measured cortical thickness of anterior temporal and orbitofrontal regions interconnected by these tracts. Thirty-three patients with PPA and 26 healthy controls were recruited.

Results

In keeping with the PPA diagnosis, behavioral symptoms were distinctly less prominent than the language

SUBMITTER: D'Anna L 

PROVIDER: S-EPMC4831038 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature