Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer.

ABSTRACT:

Background

c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the c-Myc gene locus, therefore a direct transcriptional regulation by STAT5 remains uncertain. c-Myc super-enhancer, located 1.7 Mb downstream of the c-Myc gene locus, was recently reported as essential for the regulation of c-Myc gene expression by hematopoietic transcription factors and bromodomain and extra-terminal (BET) proteins and for leukemia maintenance. c-Myc super-enhancer is composed of five regulatory regions (E1-E5) which recruit transcription and chromatin-associated factors, mediating chromatin looping and interaction with the c-Myc promoter.

Results

We now show that STA

SUBMITTER: Pinz S 

PROVIDER: S-EPMC4831086 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature