Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats.

ABSTRACT:

Background

Nonalcoholic steatohepatitis (NASH) is characterized by fat accumulation in the hepatocyte, inflammation, liver cell injury, and varying degrees of fibrosis, and can lead to oxidative stress in liver. Here, we investigated whether Salidroside, a natural phenolic antioxidant product, can protect rat from liver injury during NASH.

Methods

NASH model was established by feeding the male SD rats with high-fat and high-cholesterol diet for 14 weeks. Four groups of male SD rats including, normal diet control group, NASH model group, and Salidroside treatment group with150mg/kg and 300 mg/kg respectively, were studied. Salidroside was given by oral administration to NASH in rats from 9 weeks to 14 weeks. At the end of 14 weeks, liver and serum were harvested, and the live

SUBMITTER: Yang ZR 

PROVIDER: S-EPMC4831194 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature