Evolution of changes in cognitive function after the initiation of antiretroviral therapy.

ABSTRACT:

Background

Cognitive function is reported to improve after the initiation of combination antiretroviral therapy (cART). Data on the evolution of such changes are limited. We assessed the dynamics of changes in cognitive parameters, in HIV-positive subjects initiating cART.

Methods

Cognitive function in seven domains was evaluated for HIV-infected patients without clinically significant cognitive impairment prior to the initiation of cART, and 24 and 48 weeks after. Cognitive scores were transformed using standardised z-scores according to the pooled baseline standard deviation. Global, speed, and accuracy composite z-scores were calculated with changes calculated using a paired t test.

Results

In 14 subjects, change in global cognitive z-scores from baseline was by 0.

SUBMITTER: Mora-Peris B 

PROVIDER: S-EPMC4831200 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature