Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice.

ABSTRACT:

Background and purpose

Numerous in vitro studies have suggested that digoxin suppresses inflammation and alters lipid metabolism. However, the effect of dioxin on atherosclerosis is poorly understood. The present study was conducted to determine whether digoxin affects the development of atherosclerosis in a murine model of atherosclerotic disease.

Experimental approach

Apolipoprotein E-deficient mice maintained on a Western-type diet were administered PBS (control), low-dose digoxin (1 mg · kg(-1) · day(-1)) or high-dose digoxin (2 mg · kg(-1) · day(-1)) via i.p. injection for 12 weeks.

Key results

Digoxin dose-dependently reduced atherosclerotic lesion formation and plasma lipid levels (reductions of 41% in total cholesterol, 54% in triglycerides and 20% in low-dens

SUBMITTER: Shi H 

PROVIDER: S-EPMC4831306 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature