Ontology highlight
ABSTRACT:
SUBMITTER: Tsou LK
PROVIDER: S-EPMC4831573 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160216 7
Traditional Chinese Medicines (TCMs) have been historically used to treat bacterial infections. However, the molecules responsible for these anti-infective properties and their potential mechanisms of action have remained elusive. Using a high-throughput assay for type III protein secretion in Salmonella enterica serovar Typhimurium, we discovered that several TCMs can attenuate this key virulence pathway without affecting bacterial growth. Among the active TCMs, we discovered that baicalein, a ...[more]