Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.

ABSTRACT: Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.

SUBMITTER: Yan S 

PROVIDER: S-EPMC4831628 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature