Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.

ABSTRACT: Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent m

SUBMITTER: Fox MD 

PROVIDER: S-EPMC4831649 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature