Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes.

ABSTRACT:

Background

Natural surfactant preparations, commonly isolated from porcine or bovine lungs, are used to treat respiratory distress syndrome in preterm infants. Besides biophysical effectiveness, several studies have documented additional immunomodulatory properties. Within the near future, synthetic surfactant preparations may be a promising alternative. CHF5633 is a new generation reconstituted synthetic surfactant preparation with defined composition, containing dipalmitoyl-phosphatidylcholine, palmitoyl-oleoyl-phosphatidylglycerol and synthetic analogs of surfactant protein (SP-) B and SP-C. While its biophysical effectiveness has been demonstrated in vitro and in vivo, possible immunomodulatory abilities are currently unknown.

Aim

The aim of the current study was to defi

SUBMITTER: Fehrholz M 

PROVIDER: S-EPMC4831819 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature