Ontology highlight
ABSTRACT:
SUBMITTER: Baeza-Raja B
PROVIDER: S-EPMC4831919 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cell reports 20151231 2
Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75(NTR)) controls energy expenditure in obese mice on a high-fat diet (HFD). Despite no changes in food intake, p75(NTR)-null mice were protected from HFD-induced obesity and remained lean as a result of increased energy expenditure without developing insulin resistance or liver steatosis. p75(NTR) directly interacts with the catalytic ...[more]