Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study.

ABSTRACT:

Background

Vagal nerve blockade (vBloc) therapy was shown to be a safe and effective treatment for moderate to severe obesity. This report summarizes the safety and efficacy of vBloc therapy in the prespecified subgroup of patients with moderate obesity.

Methods

The ReCharge Trial is a double-blind, randomized controlled clinical trial of participants with body mass index (BMI) of 40-45 or 35-40 kg/m(2) with at least one obesity-related comorbid condition. Participants were randomized 2:1 to implantation with either a vBloc or sham device with weight management counseling. Eighty-four subjects had moderate obesity (BMI 35-40 kg/m(2)) at randomization.

Results

Fifty-three participants were randomized to vBloc and 31 to sham. Qualifying obesity-related comorbidities inc

SUBMITTER: Morton JM 

PROVIDER: S-EPMC4831996 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature