Ontology highlight
ABSTRACT:
SUBMITTER: Mayer CE
PROVIDER: S-EPMC4832341 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
European journal of immunology 20160118 4
Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit β5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that β5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has complet ...[more]