Molecular profiling of ETS and non-ETS aberrations in prostate cancer patients from northern India.

ABSTRACT:

Background

Molecular stratification of prostate cancer (PCa) based on genetic aberrations including ETS or RAF gene-rearrangements, PTEN deletion, and SPINK1 over-expression show clear prognostic and diagnostic utility. Gene rearrangements involving ETS transcription factors are frequent pathogenetic somatic events observed in PCa. Incidence of ETS rearrangements in Caucasian PCa patients has been reported, however, occurrence in Indian population is largely unknown. The aim of this study was to determine the prevalence of the ETS and RAF kinase gene rearrangements, SPINK1 over-expression, and PTEN deletion in this cohort.

Methods

In this multi-center study, formalin-fixed paraffin embedded (FFPE) PCa specimens (n = 121) were procured from four major medical institutions in

SUBMITTER: Ateeq B 

PROVIDER: S-EPMC4832366 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature