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The use of human sewage screening for community surveillance of hepatitis E virus in the UK.

ABSTRACT: Hepatitis E virus sequences were detected by RT-PCR in 14/15 (93%) of untreated sewage samples from Edinburgh, Scotland, UK. Phylogenetic analysis of amplicons at limiting dilution revealed the co-circulation of multiple variants of HEV-3, with a pattern of diversity matching that observed in a local cohort of HEV-infected hepatitis patients.

SUBMITTER: Smith DB 

PROVIDER: S-EPMC4832372 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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The use of human sewage screening for community surveillance of hepatitis E virus in the UK.

Smith Donald B DB   Paddy Julius O JO   Simmonds Peter P  

Journal of medical virology 20151104 5

Hepatitis E virus sequences were detected by RT-PCR in 14/15 (93%) of untreated sewage samples from Edinburgh, Scotland, UK. Phylogenetic analysis of amplicons at limiting dilution revealed the co-circulation of multiple variants of HEV-3, with a pattern of diversity matching that observed in a local cohort of HEV-infected hepatitis patients. ...[more]

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