Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma.

ABSTRACT:

Objective

To assess whether Parkinson disease (PD) genes are somatically mutated in cutaneous melanoma (CM) tissue, because CM occurs in patients with PD at higher rates than in the general population and PD is more common than expected in CM cohorts.

Methods

We cross-referenced somatic mutations in metastatic CM detected by whole-exome sequencing with the 15 known PD (PARK) genes. We computed the empirical distribution of the sum of mutations in each gene (Smut) and of the number of tissue samples in which a given gene was mutated at least once (SSampl) for each of the analyzable genes, determined the 90th and 95th percentiles of the empirical distributions of these sums, and verified the location of PARK genes in these distributions. Identical analyses were applied to aden

SUBMITTER: Inzelberg R 

PROVIDER: S-EPMC4832432 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature