Screening of whole genome sequences identified high-impact variants for stallion fertility.

ABSTRACT:

Background

Stallion fertility is an economically important trait due to the increase of artificial insemination in horses. The availability of whole genome sequence data facilitates identification of rare high-impact variants contributing to stallion fertility. The aim of our study was to genotype rare high-impact variants retrieved from next-generation sequencing (NGS)-data of 11 horses in order to unravel harmful genetic variants in large samples of stallions.

Methods

Gene ontology (GO) terms and search results from public databases were used to obtain a comprehensive list of human und mice genes predicted to participate in the regulation of male reproduction. The corresponding equine orthologous genes were searched in whole genome sequence data of seven stallions and four

SUBMITTER: Schrimpf R 

PROVIDER: S-EPMC4832559 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature