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Coronary arteriovenous malformation presenting with acute myocardial infarction.

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SUBMITTER: Ng CT

PROVIDER: S-EPMC4832816 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Coronary arteriovenous malformation presenting with acute myocardial infarction.

Ng Choon Ta CT Wong Aaron A Cheah Foong-Koon FK Ching Chi Keong CK

Heart Asia 20130123 1

PMID: 27326063

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Project description:BackgroundThe percentage of women <50 years of age hospitalized with myocardial infarction is increasing. We describe the clinical, morphological, and biological characteristics, as well as the clinical outcomes of this population.Methods and resultsThis prospective, observational study included consecutive women <50 years of age admitted for myocardial infarction at 30 centers in France (May 2017-June 2019). The primary outcome was the composite of net adverse clinical events: all-cause death, cardiovascular death, recurrent myocardial infarction, stent thrombosis, any stroke, or major bleeding occurring during hospitalization with a 12-month follow up. Three hundred fourteen women were included. The mean age was 43.0 (±5.7) years, 60.8% presented with ST-segment-elevation myocardial infarction, 75.5% were current smokers, 31.2% had a history of complicated pregnancy, and 55.1% reported recent emotional stress. Most (91.6%) women presented with typical chest pain. Of patients on an estrogen-containing contraceptive, 86.0% had at least 1 contraindication. Of patients with ST-segment-elevation myocardial infarction, 17.8% had myocardial infarction with nonobstructive coronary arteries and 14.6% had spontaneous coronary artery dissection, whereas 29.3% presented with multivessel vessel disease. During hospitalization, 11 net adverse clinical events occurred in 9 (2.8%) women, but no deaths or stent thromboses occurred. By 12 months, 14 net adverse clinical events occurred in 10 (3.2%) women; 2 (0.6%) died (from progressive cancer) and 25 (7.9%) had an ischemia-driven repeat percutaneous coronary intervention.ConclusionsMost young women with myocardial infarction reported typical chest pain and had modifiable cardiovascular risk factors. History of adverse pregnancy outcomes and prescription of combined oral contraceptive despite a contraindication were prevalent, emphasizing the need for comprehensive cardiological and gynecological evaluation and follow-up.RegistrationURL: https://www.clinicaltrials.gov; Unique identifier: NCT03073447.

Dataset Information

Coronary arteriovenous malformation presenting with acute myocardial infarction.

Publications

Coronary arteriovenous malformation presenting with acute myocardial infarction.

Similar Datasets

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