Vitamin D analogues to target residual proteinuria: potential impact on cardiorenal outcomes.

ABSTRACT: Residual proteinuria, the amount of proteinuria that remains during optimally dosed renin-angiotensin-aldosterone system (RAAS) blockade, is an independent risk factor for progressive renal function loss and cardiovascular complications in chronic kidney disease (CKD) patients. Dual RAAS blockade may reduce residual proteinuria but without translating into improved cardiorenal outcomes at least in diabetic nephropathy; rather, dual RAAS blockade may increase the risk of adverse events. These findings have challenged the concept of residual proteinuria as an absolute treatment target. Therefore, new strategies must be explored to address whether by further reduction of residual proteinuria using interventions not primarily targeting the RAAS benefit in terms of cardiorenal risk reduction wo

SUBMITTER: Humalda JK 

PROVIDER: S-EPMC4832986 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature