Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan.

ABSTRACT:

Background

In cardiovascular disease phenotypes, a genetic factor is an important determinant of both familial and non-familial dilated cardiomyopathies. Resistin is a novel adipocyte derived peptide, associated with inflammation and suggested to be involved in contractile abnormalities of cardiomyocytes.

Methods

In this study, we examined the association of the RETN SNPs in - 420 and + 299 in patients with idiopathic dilated cardiomyopathy (IDCM). Patients with IDCM (n = 250) and healthy controls (n = 250) were enrolled in this study. RETN genotyping was performed by using PCR-RFLP method.

Results

RETN - 420C > G and + 299G > A polymorphisms were significantly more prevalent in patient group vs. controls (P < 0.0001 and P = 0.0007, respectively). GG genotype at - 420

SUBMITTER: Hussain S 

PROVIDER: S-EPMC4833058 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature