Creatinine-based equations for the adjustment of drug dosage in an obese population.

ABSTRACT:

Aim

For drug dosing adaptation, the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend using estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, after 'de-indexation' by body surface area (BSA). In pharmacology, the Cockcroft-Gault (CG) equation is still recommended to adapt drug dosage. In the context of obesity, adjusted ideal body weight (AIBW) is sometimes preferred to actual body weight (ABW) for the CG equation. The aim of the present study was to compare the performance of the different GFR-estimating equations, non-indexed or de-indexed by BSA for the purpose of drug-dosage adaptation in obese patients.

Methods

We analysed data from patients with a body mass index (BMI) higher th

SUBMITTER: Bouquegneau A 

PROVIDER: S-EPMC4833161 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature