Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach.

ABSTRACT:

Aim

The objective of this study was to investigate whether the pharmacokinetics of orally administered levofloxacin show 24 h variation. Levofloxacin was used as a model compound for solubility and permeability independent absorption and passive renal elimination.

Methods

In this single centre, crossover, open label study, 12 healthy subjects received an oral dose of 1000 mg levofloxacin at six different time points equally divided over the 24 h period. Population pharmacokinetic modelling was used to identify potential 24 h variation in the pharmacokinetic parameters of this drug.

Results

The pharmacokinetics of levofloxacin could be described by a one compartment model with first order clearance and a transit compartment to describe drug absorption. The fit of the m

SUBMITTER: Kervezee L 

PROVIDER: S-EPMC4833164 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature