Genetic Variants of Angiotensin-Converting Enzyme Are Linked to Autism: A Case-Control Study.

ABSTRACT:

Background

Autism is a disease of complex nature with a significant genetic component. The importance of renin-angiotensin system (RAS) elements in cognition and behavior besides the interaction of angiotensin II (Ang II), the main product of angiotensin-converting enzyme (ACE), with neurotransmitters in CNS, especially dopamine, proposes the involvement of RAS in autism. Since the genetic architecture of autism has remained elusive, here we postulated that genetic variations in RAS are associated with autism.

Methods

Considering the relation between the three polymorphisms of ACE (I/D, rs4343 and rs4291) with the level of ACE activity, we have investigated this association with autism, in a case-control study. Genotype and allele frequencies of polymorphisms were determined

SUBMITTER: Firouzabadi N 

PROVIDER: S-EPMC4833406 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature