Highly sensitive and ultrafast read mapping for RNA-seq analysis.

ABSTRACT: As sequencing technologies progress, the amount of data produced grows exponentially, shifting the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping solutions for RNA-seq leave room for improvement in terms of sensitivity and performance, hindering an efficient analysis of transcriptomes by massive sequencing. Here, we present an innovative approach that combines re-engineering, optimization and parallelization. This solution results in a significant increase of mapping sensitivity over a wide range of read lengths and substantial shorter runtimes when compared with current RNA-seq mapping methods available.

SUBMITTER: Medina I 

PROVIDER: S-EPMC4833417 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature