Genome-wide survey of codons under diversifying selection in a highly recombining bacterial species, Helicobacter pylori.

ABSTRACT: Selection has been a central issue in biology in eukaryotes as well as prokaryotes. Inference of selection in recombining bacterial species, compared with clonal ones, has been a challenge. It is not known how codons under diversifying selection are distributed along the chromosome or among functional categories or how frequently such codons are subject to mutual homologous recombination. Here, we explored these questions by analysing genes present in >90% among 29 genomes of Helicobacter pylori, one of the bacterial species with the highest mutation and recombination rates. By a method for recombining sequences, we identified codons under diversifying selection (dN/dS> 1), which were widely distributed and accounted for ∼0.2% of all the codons of the genome. The codons were enriched in ge

SUBMITTER: Yahara K 

PROVIDER: S-EPMC4833421 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature