Spatially coordinated replication and minimization of expression noise constrain three-dimensional organization of yeast genome.

ABSTRACT: Despite recent advances, the underlying functional constraints that shape the three-dimensional organization of eukaryotic genome are not entirely clear. Through comprehensive multivariate analyses of genome-wide datasets, we show that cis and trans interactions in yeast genome have significantly distinct functional associations. In particular, (i) the trans interactions are constrained by coordinated replication and co-varying mutation rates of early replicating domains through interactions among early origins, while cis interactions are constrained by coordination of late replication through interactions among late origins; (ii)cis and trans interactions exhibit differential preference for nucleosome occupancy; (iii)cis interactions are also constrained by the essentiality and co-fitness

SUBMITTER: Singh A 

PROVIDER: S-EPMC4833423 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature