Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway.

ABSTRACT: Post-operative adhesions are a critical problem in pelvic and abdominal surgery despite a multitude of studies dedicated to finding modalities to prevent their occurrence. Ghrelin administration promotes an anti-fibrotic response in a surgical mouse model of adhesion-induction, but the mechanisms mediating this effect have not been established. In the current study, the molecular mechanisms that underlie the anti-adhesion effect of ghrelin were investigated. Post-surgical adhesions were experimentally created in C57BL/6 wild-type mice via a combination of ischemic peritoneal buttons and cecal multiple abrasions. Ghrelin or saline intraperitoneal injections were given twice daily from two days before surgery to selected time points post-surgically to assess the phenotypic and molecular effe

SUBMITTER: Bianchi E 

PROVIDER: S-EPMC4833425 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature