Protein-protein interaction network analysis of cirrhosis liver disease.

ABSTRACT:

Aim

Evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research.

Background

In clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. Evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. Since the early detection of cirrhosis is a clinical problem, achieving a sensitive, specific and predictive novel method based on biomarkers is an important task.

Methods

Essential analysis, such as gene ontology (GO) enrichment and protein-protein interactions (PPI) was undergone EXPASy, STRING Database and DAVID Bioinformatics Resources query.

Results

Based on GO analysis, most of pr

SUBMITTER: Safaei A 

PROVIDER: S-EPMC4833850 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature