Ontology highlight
ABSTRACT:
SUBMITTER: Sotoca AM
PROVIDER: S-EPMC4833872 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Oncogene 20150706 15
The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulates the normal ERG transcription program is unclear. Here, we show that FUS-ERG acts in the context of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LMO2, RUNX1 and TAL1) central to ...[more]