Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level.

ABSTRACT:

Background

Emerging data suggest that innate immunity may play a role in asthma, particularly the toll-like receptors (TLRs). Some studies pointed to an involvement of TLRs 2 and 4 in the pathogenesis of allergic asthma, and other studies related TLRs to IgE. However, there are not any studies that have comprehensively evaluated the expression of TLRs 2 and 4 in inflammatory cells, in peripheral blood and induced sputum specimens from asthmatic patients, according to their total serum IgE.

Methods

We studied 44 asthmatic patients (15 with high total serum IgE and 29 with normal total serum IgE). On a single visit, all patients underwent: induced sputum, pulmonary function tests, determination of exhaled nitric oxide fraction, venipuncture for blood analysis and skin prick al

SUBMITTER: Crespo-Lessmann A 

PROVIDER: S-EPMC4833957 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature