Hyperbaric oxygen therapy improves colorectal anastomotic healing.

ABSTRACT:

Purpose

Hyperbaric oxygen treatment (HBOT) has been found to improve the healing of poorly oxygenated tissues. This study aimed to investigate the influence of HBOT on the healing in ischemic colorectal anastomosis.

Methods

Forty Wistar rats were randomly divided into a treatment group that received HBOT for 10 consecutive days (7 days before and 3 days after surgery), or in a control group, which did not receive the therapy. Colectomy with an ischemic anastomosis was performed in all rats. In each group, the rats were followed for 3 or 7 days after surgery to determine the influence of HBOT on anastomotic healing.

Results

Five rats from each group died during follow-up. No anastomotic dehiscence was seen in the HBOT group, compared to 37.5 % and 28.6 % dehiscence in

SUBMITTER: Boersema GSA 

PROVIDER: S-EPMC4834105 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature