International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract.

ABSTRACT:

Purpose

This project aimed to reach consensus on the most appropriate animal models and outcome measures in research on anastomoses in the lower gastrointestinal tract (GIT). The physiology of anastomotic healing remains an important research topic in gastrointestinal surgery. Recent results from experimental studies are limited with regard to comparability and clinical translation.

Methods

PubMed and EMBASE were searched for experimental studies investigating anastomotic healing in the lower GIT published between January 1, 2000 and December 31, 2014 to assess currently used models. All corresponding authors were invited for a Delphi-based analysis that consisted of two online survey rounds followed by a final online recommendation survey to reach consensus on the discussed

SUBMITTER: Bosmans JWAM 

PROVIDER: S-EPMC4834109 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature