Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

ABSTRACT:

Background & aims

Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation and sepsis-induced death.

Methods

Sepsis was induced by lipopolysaccharide (LPS) or cecal ligation and puncture (CLP). The inhibitory effects of IL-30 on septic inflammation and associated therapeutic effects were determined in wild-type, IL30 (p28)(-/-), IL10(-/-), and CD1d(-/-) mice.

Results

Mice treated with pIL30 gene therapy or recombinant IL-30 protein (rIL30) were protected from LPS-induced septic shock or CLP-induced polymicrobial sepsis and show

SUBMITTER: Yan J 

PROVIDER: S-EPMC4834232 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature