Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case-Control Study.

ABSTRACT:

Purpose

Genomic DNA hypomethylation is a hallmark of most cancer genomes, promoting genomic instability and cell transformation. In the present study, we sought to determine whether global DNA methylation in peripheral blood is associated with risk of renal cell carcinoma (RCC).

Experimental design

A retrospective case-control study consisting of 889 RCC cases and an equal number of age, gender, and ethnicity-matched controls was applied. Global DNA methylation was measured as 5-mC% content. Logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for the association between DNA methylation level and the risk of RCC.

Results

The median 5-mC% was significantly lower in cases than in healthy controls (P< 0.001). In multivariate logistic

SUBMITTER: Mendoza-Perez J 

PROVIDER: S-EPMC4834236 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature