External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients.

ABSTRACT:

Aim

Several tacrolimus population pharmacokinetic models in adult renal transplant recipients have been established to facilitate dose individualization. However, their applicability when extrapolated to other clinical centres is not clear. This study aimed to (1) evaluate model external predictability and (2) analyze potential influencing factors.

Methods

Published models were screened from the literature and were evaluated using an external dataset with 52 patients (609 trough samples) collected by postoperative day 90 via methods that included (1) prediction-based prediction error (PE%), (2) simulation-based prediction- and variability-corrected visual predictive check (pvcVPC) and normalized prediction distribution error (NPDE) tests and (3) Bayesian forecasting to asses

SUBMITTER: Zhao CY 

PROVIDER: S-EPMC4834594 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature