A bisphosphonate for ¹⁹F-magnetic resonance imaging.

ABSTRACT: ¹⁹F-magnetic resonance imaging (MRI) is a promising technique that may allow us to measure the concentration of exogenous fluorinated imaging probes quantitatively in vivo. Here, we describe the synthesis and characterisation of a novel geminal bisphosphonate (¹⁹F-BP) that contains chemically-equivalent fluorine atoms that show a single and narrow ¹⁹F resonance and a bisphosphonate group that may be used for labelling inorganic materials based in calcium phosphates and metal oxides. The potential of ¹⁹F-BP to provide contrast was analysed in vitro and in vivo using ¹⁹F-MRI. In vitro studies demonstrated the potential of ¹⁹F-BP as an MRI contrast agent in the millimolar concentration range with sig

SUBMITTER: Kenny GD 

PROVIDER: S-EPMC4834630 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature