Deubiquitinases (DUBs) and DUB inhibitors: a patent review.

ABSTRACT:

Introduction

Deubiquitinating-enzymes (DUBs) are key components of the ubiquitin-proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin from substrates. DUBs contribute to activation/deactivation, recycling and localization of numerous regulatory proteins, and thus play major roles in diverse cellular processes. Altered DUB activity is associated with a multitudes of pathologies including cancer. Therefore, DUBs represent novel candidates for target-directed drug development.

Areas covered

The article is a thorough review/accounting of patented compounds targeting DUBs and stratifying/classifying the patented compounds based on: chemical-structures, nucleic-acid compositions, modes-of-action, and targeting sites. The review provides a brief ba

SUBMITTER: Farshi P 

PROVIDER: S-EPMC4834700 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature