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A decision-theoretic phase I-II design for ordinal outcomes in two cycles.

ABSTRACT: This paper is motivated by a phase I-II clinical trial of a targeted agent for advanced solid tumors. We study a stylized version of this trial with the goal to determine optimal actions in each of two cycles of therapy. A design is presented that generalizes the decision-theoretic two-cycle design of Lee and others (2015. Bayesian dose-finding in two treatment cycles based on the joint utility of efficacy and toxicity. Journal of the American Statistical Association, to appear) to accommodate ordinal outcomes. Backward induction is used to jointly optimize the actions taken for each patient in each of the two cycles, with the second action accounting for the patient's cycle 1 dose and outcomes. A simulation study shows that simpler designs obtained by dichotomizing the ordinal outcomes either perform very similarly to the proposed design, or have much worse performance in some scenarios. We also compare the proposed design with the simpler approaches of optimizing the doses in each cycle separately, or ignoring the distinction between cycles 1 and 2.

SUBMITTER: Lee J

PROVIDER: S-EPMC4834949 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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A decision-theoretic phase I-II design for ordinal outcomes in two cycles.

Lee Juhee J Thall Peter F PF Ji Yuan Y Müller Peter P

Biostatistics (Oxford, England) 20151109 2

This paper is motivated by a phase I-II clinical trial of a targeted agent for advanced solid tumors. We study a stylized version of this trial with the goal to determine optimal actions in each of two cycles of therapy. A design is presented that generalizes the decision-theoretic two-cycle design of Lee and others (2015. Bayesian dose-finding in two treatment cycles based on the joint utility of efficacy and toxicity. Journal of the American Statistical Association, to appear) to accommodate o ...[more]

PMID: 26553915

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Project description:The selection and assessment process of appropriate robots became a more complex and complicated task due to various available alternatives and conflicting attributes which must take into consideration. Also, uncertainty which exists usually in the selection process is an unavoidable component that needs to be thoughtfully measured and traditional multi-attribute decision-making approaches failed to deal precisely with it. Since almost all decisions originate from subjective ordinal preferences, handling uncertainty using linguistic variables is also not enough. Thus, the objective of the current study is to present a new extended ordinal priority approach in the neutrosophic environment for the first time to select an appropriate robot. Since neutrosophic is one of the most effective and accommodating tools for handling uncertainty, thus, this method goes to transform linguistic information into triangular neutrosophic numbers using a new presented scale. This scale was used to determine the importance degree of attributes and alternatives regarding experts' opinions. Also, the score function of the triangular neutrosophic number is used for prioritizing attributes and alternatives. The experts in our proposed method have the same degree of importance, since each expert is a person with special skills and knowledge representing mastery of a particular subject. To measure the applicability and efficiency of the proposed approach, an experimental case study has been established for the robot selection problem of a new pharmaceutical city in Egypt for the first time. The source of data in this case study is experts, interviews, and questionnaires. Also, sensitivity and comparative analysis are further made for verifying the power of the proposed approach. The outcome of this study shows that the suggested approach for robot selection is quite helpful and has a great performance under uncertainty over classical and fuzzy ordinal priority approaches. Also, the suggested approach is less consumption of time and simpler than the fuzzy ordinal priority approach. Therefore, we recommend firms and governments to apply it for increasing product quality, hence the profitability of manufacturing industries and decrease needless costs.Supplementary informationThe online version contains supplementary material available at 10.1007/s40747-022-00721-w.

Dataset Information

A decision-theoretic phase I-II design for ordinal outcomes in two cycles.

Publications

A decision-theoretic phase I-II design for ordinal outcomes in two cycles.

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