Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans.

ABSTRACT:

Background

Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.

Methods

Quantitative DNA methylation analysis in Indians and Europeans using Sequenom^® EpiTYPER^® technology was undertaken in three genes: ADCY5, FTO and KCNJ11. Metabolic measures and genotype data we

SUBMITTER: Elliott HR 

PROVIDER: S-EPMC4835020 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature