Tracking Resilience to Infections by Mapping Disease Space.

ABSTRACT: Infected hosts differ in their responses to pathogens; some hosts are resilient and recover their original health, whereas others follow a divergent path and die. To quantitate these differences, we propose mapping the routes infected individuals take through "disease space." We find that when plotting physiological parameters against each other, many pairs have hysteretic relationships that identify the current location of the host and predict the future route of the infection. These maps can readily be constructed from experimental longitudinal data, and we provide two methods to generate the maps from the cross-sectional data that is commonly gathered in field trials. We hypothesize that resilient hosts tend to take small loops through disease space, whereas nonresilient individuals tak

SUBMITTER: Torres BY 

PROVIDER: S-EPMC4835107 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature