Nonbenzodiazepine Sedative Hypnotics and Risk of Fall-Related Injury.

ABSTRACT:

Study objectives

The objective of this study was to test the hypothesis that use of zolpidem, eszopiclone, and zaleplon would be associated with increased risk of traumatic brain injury (TBI) and hip fracture.

Methods

We conducted a case-crossover study on a 5% random sample of Medicare beneficiaries age 65 y or older hospitalized with either TBI (n = 15,031) or hip fracture (n = 37,833) during 2007-2009. Use of zolpidem, eszopiclone, or zaleplon during the 30-day period prior to injury hospitalization was compared to use during four control periods at 3, 6, 9, and 12 mo prior to injury. The primary outcome was hospitalization for TBI or hip fracture.

Results

Zolpidem use during the month prior to injury was associated with increased risk of TBI (odds ratio [OR] 1.87;

SUBMITTER: Tom SE 

PROVIDER: S-EPMC4835298 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature