Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults.

ABSTRACT:

Study objectives

To determine the association between self-reported sleep duration and cortical thinning among older adults.

Methods

We studied 122 cognitively normal participants in the Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51-84) at baseline sleep assessment and 69.5 y (range, 56-86) at initial magnetic resonance imaging (MRI) scan. Participants reported average sleep duration and completed a mean of 7.6 1.5-T MRI scans (range, 3-11), with mean follow-up from initial scan of 8.0 y (range, 2.0-11.8).

Results

In analyses adjusted for age, sex, education, race, and interval between sleep assessment and initial MRI scan, participants reporting > 7 h sleep at baseline had thinner cortex in the inferior occipital gyrus and sulcus of the le

SUBMITTER: Spira AP 

PROVIDER: S-EPMC4835311 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature