Safety of artemisinins in first trimester of prospectively followed pregnancies: an observational study.

ABSTRACT:

Background

Artemisinins, the most effective antimalarials available, are not recommended for falciparum malaria during the first trimester of pregnancy because of safety concerns. Therefore, quinine is used despite its poor effectiveness. Assessing artemisinin safety requires weighing the risks of malaria and its treatment. We aimed to assess the effect of first-trimester malaria and artemisinin treatment on miscarriage and major congenital malformations.

Methods

In this observational study, we assessed data from antenatal clinics on the Thai-Myanmar border between Jan 1, 1994, and Dec 31, 2013. We included women who presented to antenatal clinics during their first trimester with a viable fetus. Women were screened for malaria, and data on malaria, antimalarial treatment, a

SUBMITTER: Moore KA 

PROVIDER: S-EPMC4835584 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature