Advances of Targeted Therapy in Treatment of Unresectable Metastatic Colorectal Cancer.

ABSTRACT: Despite being one of the most frequently diagnosed cancers worldwide, prognosis of metastatic colorectal cancer (CRC) was poor. Development and introduction of biologic agents in treatment of patients with metastatic CRC have brought improved outcomes. Monoclonal antibodies directing epidermal growth factor receptors and vascular endothelial growth factor are main biologic agents currently used in treatment of metastatic CRC. Encouraged by results from many clinical trials demonstrating efficacy of those monoclonal antibodies, the combination therapy with those targeted agents and conventional chemotherapeutic agents has been established as the standard therapy for patients with metastatic CRC. However, emergency of resistance to those target agents has limited the efficacy of treatment, a

SUBMITTER: Lee SY 

PROVIDER: S-EPMC4835624 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature