Drinking and mortality: long-term follow-up of drinking-discordant twin pairs.

ABSTRACT:

Aims

To determine if associations of alcohol consumption with all-cause mortality replicate in discordant monozygotic twin comparisons that control for familial and genetic confounds.

Design

A 30-year prospective follow-up.

Setting

Population-based older Finnish twin cohort.

Participants

Same-sex twins, aged 24-60 years at the end of 1981, without overt comorbidities, completed questionnaires in 1975 and 1981 with response rates of 89 and 84%. A total of 15,607 twins were available for mortality follow-up from the date of returned 1981 questionnaires to 31 December 2011; 14,787 twins with complete information were analysed.

Measurements

Self-reported monthly alcohol consumption, heavy drinking occasions (HDO) and alcohol-induced blackouts. Adjustments fo

SUBMITTER: Sipila P 

PROVIDER: S-EPMC4835818 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature