Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer.

ABSTRACT:

Background

The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphatic injections, limiting their feasibility. Here, we report on the feasibility and safety of a new method of long-term repetitive intralymphatic (IL) infusion of immune cells, using implantable delivery ports.

Methods

Nine patients with stage IV recurrent colorectal cancer underwent complete resection and received autologous dendritic cells (DCs) loaded with killed autologous tumor cells, KLH and PADRE, for up to four monthly cycles. Leg lymphatic vessels were cannulated, connected to 6.6Fr low-profile implantable subcutaneous delivery ports, and used to infuse

SUBMITTER: Radomski M 

PROVIDER: S-EPMC4835859 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature