Protection of nitro-fatty acid against kidney diseases.

ABSTRACT: Nitrated derivatives of unsaturated fatty acids are endogenously formed under oxidative and nitrative stress condition and are defined as electrophilic fatty acids containing a nitro group to a carbon-carbon double bond. Among the most studied nitro derivatives of unsaturated fatty acids are nitro-oleic acid (OA-NO₂) and nitro-linoleic acid (LNO₂). These products exhibit novel protective actions in a variety of rodent disease models. Diverse signaling events are responsible for effects of nitrated fatty acid, including activating peroxisome proliferator-activated receptor-dependent gene expression, suppressing NF-κB-induced inflammation, inhibiting oxidative stress, and increasing both endothelial nitric oxide synthase- and Nrf2-dependent gene regulation. Nitrated fat

SUBMITTER: Wang W 

PROVIDER: S-EPMC4835926 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature