Gene signature-based mapping of immunological systems and diseases.

ABSTRACT:

Background

The immune system is multifaceted, structured by diverse components that interconnect using multilayered dynamic cellular processes. Genomic technologies provide a means for investigating, at the molecular level, the adaptations of the immune system in host defense and its dysregulation in pathological conditions. A critical aspect of intersecting and investigating complex datasets is determining how to best integrate genomic data from diverse platforms and heterogeneous sample populations to capture immunological signatures in health and disease.

Result

We focus on gene signatures, representing highly enriched genes of immune cell subsets from both diseased and healthy tissues. From these, we construct a series of biomaps that illustrate the molecular linkages be

SUBMITTER: Liu H 

PROVIDER: S-EPMC4836068 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature